HCID 86604970, compound → methyl 2-[2-(aminomethyl)phenyl]-3-cyclohexyl-1-(1,3-dioxolan-2-ylmethyl)-1H-indole-6-carboxylate

Participants

Reaction Steps

Platinum (IV) oxide (20 mol %) was added as a slurry in AcOH under N2 to a solution of methyl 3-cyclohexyl-1-(1,3-dioxolan-2-ylmethyl)-2-{2-[(hydroxyimino)methyl]phenyl}-1H-indole-6-carboxylate in AcOH (0.07 M). The atmosphere in the reaction vessel was charged with H2 at 50 psi pressure and the reaction agitated on a Parr apparatus for 48 h. The reaction was then filtered under N2 through a plug of celite, washing well with AcOH, and the filtered solution concentrated in vacuo to afford the title compound (100%); MS (ES+) m/z 449 (M+H)+.

Provenance & Evidence