HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 68509324, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-(Methylaminomethyl)pyridine | HCID 88393 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | Sodium chloride; water | HCID 57417360 | — |
| Reactant | HCID 68510603 | HCID 68510603 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 68509324 | HCID 68509324 | — |
Reaction Steps
To a solution of [14-cyclohexyl-11-(methoxycarbonyl)-7,8-dihydroindolo[2,1-a][2,5]benzodiazocin-6(5H)-yl]acetic acid in DCM (0.05 M), 3.5 eq of DIPEA, 1.5 eq of HATU and 1.5 eq of N-methyl-1-pyridin-3-ylmethanamine were added and the mixture was stirred overnight at RT. The solution was portioned between DCM and brine. The aqueous phase was re-extracted with DCM (twice) and the combined organics then dried over Na2SO4, filtered and concentrated in vacuo. The crude was used in the next step without further purification; MS (ES+) m/z 551 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795247B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-d15a667cce224826bde2e5b04fdcb03d |
| Source note | uspto-grants-2010_09 |