Morpholine → 4-Morpholinesulfonamide

Participants

Reaction Conditions

Reaction Steps

To a solution of morpholine (1 eq) in DME (0.3 M), 5 eq of sulfamide were added and the solution was heated at 100° C. overnight. The volatiles were removed in vacuo, the residue taken up in EtOAc and the organic phase washed with H2O and then brine. The organic phase was dried over Na2SO4, filtered and concentrated in vacuo to give the title compound (17%); MS (ES+) m/z 167 (M+H)+

Provenance & Evidence