Hydrochloric Acid → Donepezil Hydrochloride

Participants

Reaction Steps

After completing the hydrogenation, the catalyst was removed from the reaction solution followed by concentration. To the concentrated residue, 91 ml of ethanol was added to obtain a solution. Subsequently, the solution was crystallized under stirring. Precipitated crystals were filtered out, and then dried to obtain 10.4 g of donepezil. The obtained donepezil (10.3 g) was dissolved in 83 ml of ethanol. To the mixture, 3.1 g of concentrated hydrochloric acid was added under stirring, and the mixture was converted into its hydrochloride. The precipitated crystals were filtered out, and then dried to obtain 10.8 g of donepezil hydrochloride.

Provenance & Evidence