HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 16117541, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | (2,4-Dichlorophenyl)boronic acid | HCID 2734659 | — |
| Reactant | HCID 16117814 | HCID 16117814 | — |
| Reactant | Barium hydroxide, octahydrate | HCID 17749109 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 16117541 | HCID 16117541 | 41.2% |
Reaction Steps
The title compound (90 mg, 0.21 mmol) was prepared by following the procedure of example 3 from cis-3-benzyl-8-bromo-1,2,3,4,4a,9a-hexahydro-3-aza-fluoren-9-one (172 mg, 0.51 mmol), 2,4-dichlorophenylboronic acid (153 mg, 0.80 mmol), barium hydroxide octahydrate (317 mg, 1.0 mmol) and triphenylphosphine (18 mg, 0.067 mmol) and palladium(II) acetate (3.8 mg, 0.017 mmol) in DMF (6.0 mL)/H2O (1.2 mL): MS (ES) 422.1 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795436B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-62c7f78015bd40868a8f50e6225947b2 |
| Source note | uspto-grants-2010_09 |