Triethylamine → HCID 16117681, compound

Participants

Reaction Steps

The title compound (8.0 mg, 0.021 mmol) was prepared by following the procedure of example 17. cis-6-(2-Chloro-4-trifluoromethyl-phenyl)-8-methyl-2,3,4,4a,9,9a-hexahydro-1H-3-aza-fluorene (16 mg, 0.044 mmol) was reacted with ethyl chloroformate (9.6 mg, 0.088 mmol) and Et3N (22.3 mg, 0.22 mmol) in CH2Cl2 (0.5 mL) to give cis-6-(2-chloro-4-trifluoromethyl-phenyl)-8-methyl-1,2,4,4a,9,9a-hexahydro-3-aza-fluorene-3-carboxylic acid ethyl ester (12 mg, 0.027 mmol) which was reduced with LiAlH4 (2.1 mg, 0.055 mmol) in THF (1 mL): MS (ES) 380.1 (M+H).

Provenance & Evidence