Formic Acid → HCID 57819985, compound

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Reaction Steps

A solution of 4-formylcinnamic acid methyl ester (3.66 g, 19.2 mmol), 4-(trifluoromethyl)-phenyl isocyanide (3.32 g, 19.2 mmol), 2-morpholinoethylamine (2.50 g, 19.2 mmol) and formic acid solution in methanol (12.9 mL, 1.5M) in methanol (9 mL) was stirred at 80 degrees Celcius for 8 hours. After solvent removal, the crude product was directly purified by flash column chromatography over silica gel (dichloromethane/methanol, 100:1 to 20:1, v:v) to yield the desired product (5 g, 50.2%). MS: calc'd 520 (MH+) exp 520 (MH+).

Provenance & Evidence