Formic Acid → HCID 57820116, compound

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A solution of (E)-{2-[3-(4-formyl-phenyl)-acryloylamino]-phenyl}-carbamic acid tert-butyl ester (1.10 g, 3.00 mmol), 4-(trifluoromethyl)-phenyl isocyanide (520 mg, 3.00 mmol), 2-morpholinoethylamine (391 mg, 3.00 mmol) and formic acid solution in methanol (2.0 mL, 1.5M) in methanol (1.0 mL) was stirred at 80 degrees Celcius for 4 hours. After solvent removal, the crude product was directly purified by flash column chromatography over silica gel (dichloromethane/methanol, 100:1 to 10:1, v:v) to yield the desired product (730 mg, 35%). MS: calc'd 696 (MH+) exp 696 (MH+).

Provenance & Evidence