Methanol → HCID 59682281, compound

HRID 1714255Notes

Reaction equation

HRID 1714255 reaction equation
[BH4-].[Na+].CO.[Cl:5][C:6]1[C:24]([Cl:25])=[CH:23][C:9]2[N:10]([CH2:18][C:19](=[O:22])[CH2:20][CH3:21])[C:11]([CH2:13][C:14]([F:17])([F:16])[F:15])=[N:12][C:8]=2[CH:7]=1>O>[Cl:5][C:6]1[C:24]([Cl:25])=[CH:23][C:9]2[N:10]([CH2:18][CH:19]([OH:22])[CH2:20][CH3:21])[C:11]([CH2:13][C:14]([F:15])([F:16])[F:17])=[N:12][C:8]=2[CH:7]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 44430223HCID 44430223, compound

Product 1

HCID 59682281HCID 59682281, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium borohydride (11.16 mg, 0.2949 mmol) was added into methanol (5 mL). After the bubbling ceased, 1-[5,6-dichloro-2-(2,2,2-trifluoro-ethyl)-benzoimidazol-1-yl]-butan-2-one (19170-168) (100 mg, 0.2949 mmol) was added. The resulting mixture was stirred at room temperature for 1 hour. The resulting mixture was poured into water and then extracted with EtOAc. The organic layer was dried over anhydrous MgSO4. The solvent was distilled out under reduced pressure to yield the title compound as an off-white solid.

Workup

  1. extractionextracted with EtOAc
  2. dry with materialThe organic layer was dried over anhydrous MgSO4
  3. distillationThe solvent was distilled out under reduced pressure

Sources & evidence

ORD record
ord-af711036e19e4db595a112c1a37eb1d1
Source dataset
uspto-grants-2010_09
Patent number
US07795446B2

Reaction notes

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