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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1714286Generated: November 2, 2026

Ethanamine, 2,2,2-trifluoro- → [2-Methyl-2-(4-nitro-imidazol-1-yl)-propyl]-(2,2,2-trifluoro-ethyl)-amine

https://huagongshe.com/reaction/1714286

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthanamine, 2,2,2-trifluoro-HCID 9773—
Reactant2-Methyl-2-(4-nitro-imidazol-1-yl)-propionaldehydeHCID 86600809—
Product[2-Methyl-2-(4-nitro-imidazol-1-yl)-propyl]-(2,2,2-trifluoro-ethyl)-amineHCID 67163871—

Reaction Steps

2-Methyl-2-(4-nitro-imidazol-1-yl)-propionaldehyde was reacted with 2,2,2-trifluoro-ethyl amine to provide the title compound: H1 NMR (400 MHz, CDCl3) 1.59 (s, 6H), 2.98 (s, 2H), 3.10 (m, 2H), 7.56 (s, 1H), 7.90 (s, 1H) MS m/z 267.3 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07795447B2
Source datasetuspto-grants-2010_09
ORD IDord-c5a7ad1782ac437785f488295580098c
Source noteuspto-grants-2010_09