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HRID 1714297作成日：2026年10月26日

(2S)-2-hydroxy-3,3-dimethylbutanoic acid → 2-(2-Hydroxy-3,3-dimethyl-butyrylamino)-pentanoic acid [1-(1-ethyl-propyl)-1H-imidazol-4-yl]-amide

https://huagongshe.com/reaction/1714297

反応式

関与物質

役割名称HCID仕込み量
反応物(2S)-2-hydroxy-3,3-dimethylbutanoic acidHCID 11097105—
反応物2-Amino-pentanoic acid [1-(1-ethyl-propyl)-1H-imidazol-4-yl]-amideHCID 67165041—
生成物2-(2-Hydroxy-3,3-dimethyl-butyrylamino)-pentanoic acid [1-(1-ethyl-propyl)-1H-imidazol-4-yl]-amideHCID 11646322—

反応手順

2-Amino-pentanoic acid [1-(1-ethyl-propyl)-1H-imidazol-4-yl]-amide was coupled with (S)-2-hydroxy-3,3-dimethyl-butyric acid to provide the title compound: C13 NMR (100 MHz, CDCl3) 10.8, 13.9, 19.0, 26.3, 28.8, 35.3, 35.6, 52.7, 62.9, 79.8, 104.8, 132.7, 137.9, 169.2, 172.9; MS 367.1 m/z (M+1).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07795447B2
出典データセットuspto-grants-2010_09
ORD IDord-72a7e36d75e74ceea08b38b69ccb1933
出典メモuspto-grants-2010_09