HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-hydroxy-3,3-dimethylbutanoic acid → 3-{4-[2-(2-Hydroxy-3,3-dimethyl-butyrylamino)-propionylamino]-imidazol-1-yl}-3-methyl-butyric acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-hydroxy-3,3-dimethylbutanoic acid | HCID 11097105 | — |
| Reactant | 3-[4-(2-Amino-propionylamino)-imidazol-1-yl]-3-methyl-butyric acid methyl ester | HCID 67164944 | — |
| Product | 3-{4-[2-(2-Hydroxy-3,3-dimethyl-butyrylamino)-propionylamino]-imidazol-1-yl}-3-methyl-butyric acid methyl ester | HCID 25206340 | — |
Reaction Steps
3-[4-(2-Amino-propionylamino)-imidazol-1-yl]-3-methyl-butyric acid methyl ester was coupled with (S)-2-hydroxy-3,3-dimethyl-butyric acid to provide the title compound: C13 NMR (100 MHz, CDCl3) 19.2, 26.2, 28.1, 28.2, 35.2, 47.1, 48.6, 51.9, 56.4, 79.7, 105.1, 112.4, 131.0, 137.7, 169.7, 170.0, 173.0; MS 383.3 m/z (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795447B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-9ffca09ce7584a06a5a07c1a94a570de |
| Source note | uspto-grants-2010_09 |