6,8-Difluoro-2-tetralone → HCID 11569653, compound

HRID 1714351Notes

Reaction equation

HRID 1714351 reaction equation
[CH3:1][C:2]([N:12]1[CH:16]=[C:15]([NH:17][C:18](=[O:24])[CH:19]([NH2:23])[CH2:20][CH2:21][CH3:22])[N:14]=[CH:13]1)([CH3:11])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1.[F:25][C:26]1[CH:27]=[C:28]2[C:33](=[C:34]([F:36])[CH:35]=1)[CH2:32][C:31](=O)[CH2:30][CH2:29]2>>[CH3:1][C:2]([N:12]1[CH:16]=[C:15]([NH:17][C:18](=[O:24])[CH:19]([NH:23][CH:31]2[CH2:30][CH2:29][C:28]3[C:33](=[C:34]([F:36])[CH:35]=[C:26]([F:25])[CH:27]=3)[CH2:32]2)[CH2:20][CH2:21][CH3:22])[N:14]=[CH:13]1)([CH3:11])[CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][O:8][CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 40764316,8-Difluoro-2-tetraloneHCID 67165351HCID 67165351, compound

Product 1

HCID 11569653HCID 11569653, compound

Procedure

2-Amino-pentanoic acid [1-(1,1-dimethyl-3-morpholin-4-yl-propyl)-1H-imidazol-4-yl]-amide was reacted with 6,8-Difluoro-3,4-dihydro-1H-naphthalen-2-one to provide the title compound: 13C NMR 14.2, 19.5, 19.6, 28.2, 28.3, 28.5, 28.6, 28.6, 28.7, 28.8, 29.7, 29.8, 30.8, 36.5, 36.6, 39.8, 52.3, 52.7, 54.0, 57.2, 57.3, 60.3, 60.8, 67.1, 100.8, 101.1, 101.3, 104.6, 104.7, 110.5, 110.6, 110.8, 110.9, 130.5, 137.6, 137.7, 139.9, 159.7, 162.3, 172.3, 172.5; MS m/z 504.2 (M+1).

Sources & evidence

ORD record
ord-2346e23d79da465d8c18320dfc54e36a
Source dataset
uspto-grants-2010_09
Patent number
US07795447B2

Reaction notes

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