HCID 58101931, compound → HCID 67163808, compound

HRID 1714358Notes

Reaction equation

HRID 1714358 reaction equation
[CH3:1][C:2]([N:10]1[CH:14]=[C:13]([NH:15][C:16](=[O:22])[CH:17]([NH2:21])[CH2:18][CH2:19][CH3:20])[N:12]=[CH:11]1)([CH3:9])[CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][CH2:5]1.[CH:23]([C:26]1[CH:27]=[C:28]2[C:33](=[CH:34][CH:35]=1)[CH2:32][C:31](=O)[CH2:30][CH2:29]2)([CH3:25])[CH3:24]>>[CH3:1][C:2]([N:10]1[CH:14]=[C:13]([NH:15][C:16](=[O:22])[CH:17]([NH:21][CH:31]2[CH2:30][CH2:29][C:28]3[C:33](=[CH:34][CH:35]=[C:26]([CH:23]([CH3:25])[CH3:24])[CH:27]=3)[CH2:32]2)[CH2:18][CH2:19][CH3:20])[N:12]=[CH:11]1)([CH3:9])[CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 58101931HCID 58101931, compoundHCID 671642262-Amino-pentanoic acid [1-(1,1-dimethyl-2-pyrrolidin-1-yl-ethyl)-1H-imidazol-4-yl]-amide

Product 1

HCID 67163808HCID 67163808, compound

Procedure

2-Amino-pentanoic acid [1-(1,1-dimethyl-2-pyrrolidin-1-yl-ethyl)-1H-imidazol-4-yl]-amide was reacted with 6-Isopropyl-3,4-dihydro-1H-naphthalen-2-one to afford the title compound: C13 NMR (100 MHz, CDCl3) 14.1, 19.5, 19.6, 24.2, 26.6, 26.7, 28.2, 28.4, 29.6, 30.6, 33.9, 36.3, 36.5, 37.2, 53.4, 53.7, 56.0, 59.1, 60.3, 60.8, 67.3, 104.6, 124.1, 126.7, 126.8, 129.5, 129.6, 131.1, 132.1, 135.7, 136.0, 137.3, 146.7, 146.8, 172.4, 172.6; MS m/z 480.5 (M+1).

Sources & evidence

ORD record
ord-848eb29e2b644291888a0eeb0c0a946a
Source dataset
uspto-grants-2010_09
Patent number
US07795447B2

Reaction notes

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