HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 24956920, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Cyclobutanecarboxylic acid | HCID 19494 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 178510120 | HCID 178510120 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 24956920 | HCID 24956920 | — |
Reaction Steps
The title compound was prepared analogously to example 1 (1.5) from Trans 2-{1-[2-(4-Amino-cyclohexyl)-ethyl]-piperidin-4-yloxy}-5-fluoro-benzonitrile; trifluoro-acetic acid salt and cyclobutanecarboxylic acid using 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyl uronium tetrafluoroborate and N-ethyldiisopropylamine in dimethylformamide (DMF). The residue was taken up on methanol and purified with preparative HPLC on reversed phase eluting with acetonitrile/water. MS (m/e): 428.0. (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795437B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-127a8c3a0f164e57810162a70ba5aa3d |
| Source note | uspto-grants-2010_09 |