2-Thiophenecarboxylic acid → HCID 178510083, compound

HRID 1714400Notes

Reaction equation

HRID 1714400 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([O:16][C:17]3[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][C:18]=3[F:25])[CH2:12][CH2:11]2)[CH2:4][CH2:3]1.[S:26]1[CH:30]=[CH:29][CH:28]=[C:27]1[C:31](O)=[O:32]>>[C:21]([C:20]1[CH:23]=[CH:24][C:17]([O:16][CH:13]2[CH2:12][CH2:11][N:10]([CH2:9][CH2:8][C@H:5]3[CH2:6][CH2:7][C@H:2]([NH:1][C:31]([C:27]4[S:26][CH:30]=[CH:29][CH:28]=4)=[O:32])[CH2:3][CH2:4]3)[CH2:15][CH2:14]2)=[C:18]([F:25])[CH:19]=1)#[N:22]

Participants

3

Reactant 2

HCID 107002-Thiophenecarboxylic acidHCID 178510082HCID 178510082, compound

Product 1

HCID 178510083HCID 178510083, compound

Procedure

According to the synthesis of example 1, the title compound was prepared from Trans 4-{1-[2-(4-Amino-cyclohexyl)-ethyl]-piperidin-4-yloxy}-3-fluoro-benzonitrile and Thiophene-2-carboxylic acid. Preparative HPLC on reversed phase eluting with acetonitrile/water yielded the title compound. MS (m/e): 456.3 (M+H+).

Workup

  1. customAccording to the synthesis of example 1
  2. washPreparative HPLC on reversed phase eluting with acetonitrile/water

Sources & evidence

ORD record
ord-f795352616ba481b83070e1d0c52d77c
Source dataset
uspto-grants-2010_09
Patent number
US07795437B2

Reaction notes

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