Acetic Acid → HCID 178474970, compound

HRID 1714401Notes

Reaction equation

HRID 1714401 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][CH:14]([O:17][C:18]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:19]=3[C:20]#[N:21])[CH2:13][CH2:12]2)[CH2:5][CH2:4]1.[C:27](O)(=[O:29])[CH3:28]>>[Cl:26][C:23]1[CH:24]=[CH:25][C:18]([O:17][CH:14]2[CH2:13][CH2:12][N:11]([CH2:10][CH2:9][C@H:6]3[CH2:7][CH2:8][C@H:3]([NH:2][C:27](=[O:29])[CH3:28])[CH2:4][CH2:5]3)[CH2:16][CH2:15]2)=[C:19]([C:20]#[N:21])[CH:22]=1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 178479181HCID 178479181, compound

Product 1

HCID 178474970HCID 178474970, compound

Procedure

The title compound was prepared analogously to example 59.5 from 2-{1-[2-(trans-4-amino-cyclohexyl)-ethyl]-piperidin-4-yloxy}-5-chloro-benzonitrile hydrochloride and acetic acid. MS (m/z): 404.5 (M+H+).

Sources & evidence

ORD record
ord-0b2c03bc4779440b9b2aba1163f5c93f
Source dataset
uspto-grants-2010_09
Patent number
US07795437B2

Reaction notes

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