Pyridine → HCID 11955084, compound

Participants

Reaction Steps

At room temperature, 0.29 g of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carbonyl chloride was added dropwise to a solution of 0.36 g of 4′-trifluoromethyl-2-aminobiphenyl and 0.18 g of pyridine in 10 ml of toluene, after which the mixture was stirred at room temperature for 16 hours. 30 ml of methyl tert-butyl ether were added, and the organic phase was washed successively with 2% strength hydrochloric acid, 2% strength aqueous sodium hydroxide solution and then with dilute sodium chloride solution. The organic phase was dried and concentrated under reduced pressure. The crude product was stirred with 5 ml of diisopropyl ether. The solid that remained was separated off and dried. This gave 0.45 g of the desired product as a white powder; m.p. 164-165° C.

Provenance & Evidence