Acetic Anhydride → N-(2,3-Dihydro-1H-inden-5-yl)acetamide

Participants

Reaction Conditions

Reaction Steps

After 33.3 g (0.25 mol) of 5-aminoindane (manufactured by Tokyo Chemical Industry Co., Ltd.) was dissolved in 250 ml of glacial acetic acid, the solution was heated at 50° C., and 51.0 g (0.5 mol) of acetic anhydride was added dropwise. After the termination of the dropping, stirring was performed for 4 hours. After the termination of the reaction, the reaction solution was poured into 1500 ml of ice water with stirring. Precipitated crystals were separated by filtration, and washed with 1000 ml of water. The resulting crystals were dried to obtain 37.06 g of 5-(N-acetylamino)indane (yield: 84.6%, melting point: 100.5 to 103.5° C.).

Provenance & Evidence