Ethanol → HCID 17039033, compound

HRID 1714725Notes

Reaction equation

HRID 1714725 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][CH:18]=[CH:17][C:3]=1[C:4]([NH:6][C:7]1[S:8][CH:9]=[C:10]([C:12]([O:14]CC)=[O:13])[N:11]=1)=[O:5].[OH-].[K+].C(O)C>O>[Cl:1][C:2]1[CH:20]=[CH:19][CH:18]=[CH:17][C:3]=1[C:4]([NH:6][C:7]1[S:8][CH:9]=[C:10]([C:12]([OH:14])=[O:13])[N:11]=1)=[O:5]

Participants

5

Reactant 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 3394160HCID 3394160, compound

Product 1

HCID 17039033HCID 17039033, compoundYield 69.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A mixture of 1.52 g of ethyl 2-(2-chlorobenzoyl)amino-1,3-thiazole-4-carboxylate, 0.68 g of potassium hydroxide, 1.8 mL of water and 9 mL of ethanol was stirred at room temperature for 4 hrs. After the reaction mixture was diluted with water, it was washed with ethyl acetate. The separated aqueous phase was acidified with an aqueous 2N-hydrochloric acid solution and the precipitated crude product was washed with water and dried to obtain 0.96 g of the aimed 2-(2-chlorobenzoyl)amino-1,3-thiazole-4-carboxylic acid.

Workup

  1. washwas washed with ethyl acetate
  2. customthe precipitated crude product
  3. washwas washed with water
  4. customdried

Sources & evidence

ORD record
ord-75dc0801efe54c26b6adfcd72386ed6e
Source dataset
uspto-grants-2010_09
Patent number
US07799738B2

Reaction notes

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