反应详情

In 725 ml of 2-propanol and 365 ml of distilled water, 168.0 g of ethyl 2-[5-(4-quinolin-2-ylpiperazin-1-yl)pentanoylamino]cyclohex-1-enecarboxylate as synthesized in above Step 7-1-D was suspended. To the suspension 580 ml of 1N-aqueous sodium hydroxide was added and heated under reflux for 1.5 hours. After cooling, the reaction mixture was neutralized with 2N-hydrochloric acid. Whereupon precipitated crystals were recovered by filtration and dried to provide 131.8 g (83.4%) of 2-[5-(4-quinolin-2-ylpiperazin-1-yl)pentanoylamino]cyclohex-1-enecarboxylic acid.

1. temperatureheated
2. temperatureunder reflux for 1.5 hours
3. temperatureAfter cooling
4. customWhereupon precipitated crystals
5. filtrationwere recovered by filtration
6. customdried