Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | HCID 23155747 | HCID 23155747 | — |
| Product | HCID 23155838 | HCID 23155838 | 65% |
Reaction Steps
A mixture of 207 mg of 2-[4-(4-quinolin-2-ylpiperazin-1-yl)-butyl]-3,1-benzoxazin-4-one as synthesized in above Step 7-15-B and 150 mg of benzylamine was stirred at 250° C. for an hour. Cooling the solution, the residue was purified on silica gel column chromatography (dichloromethane:methanol=15:1) to provide 163 mg (65%) of 3-benzyl-2-[4-(4-quinolin-2-ylpiperazin-1-yl)butyl]-3H-quinazolin-4-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07799775B2 |
|---|
| Source dataset | uspto-grants-2010_09 |
|---|
| ORD ID | ord-fbe8efd77122421d91a043eab4274540 |
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| Source note | uspto-grants-2010_09 |
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