HCID 21287994, compound → HCID 23155639, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 420 mg of 3-methyl-2-methylsulfanyl-5,6,7,8-tetrahydro-3H-quinazolin-4-one as synthesized in Step 7-29-A and 540 mg of 2-[4-(3-aminopropyl)piperazin-1-yl]quinoline as synthesized in above Step 7-29-B was heated under stirring at 140° C. for 6 hours. The residue was purified on silica gel column chromatography (chloroform:methanol=10:1) to provide 420 mg (48%) of 3-methyl-2-[3-(4-quinolin-2-ylpiperazin-1-yl)propylamino]-5,6,7,8-tetrahydro-3H-quinazolin-4-one.

Provenance & Evidence