Acetone → HCID 23155628, compound

Participants

Reaction Steps

Into 10 ml of acetone, 50 mg of 7-methoxy-1-piperazin-1-ylisoquinoline, 100 mg of 4-fluorobenzyl bromide and 100 mg of triethylamine were added and heated under reflux for 5 hours. Distilling the solvent off under reduced pressure, the residue was purified on silica gel column chromatography (methanol:chloroform=1:19) to provide 52 mg (79%) of 1-[4-(4-fluorobenzyl)piperazin-1-yl]-7-methoxyisoquinoline.

Provenance & Evidence