HCID 59465198, compound → HCID 25158232, compound

Participants

Reaction Conditions

Reaction Steps

Methyl (2S)-2-[(2-amino-5-nitro-pyrimidin-4-yl)-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl]amino]propanoate (Intermediate 1)(500 mg, 1.28 mmol) was dissolved in acetic acid (4 mL) and heated to 70° C., then iron powder (144 mg, 2.58 mmol) was added. The mixture was stirred at 70° C. for 1 hour, then 100° C. for 30 minutes. The dark mixture was filtered through Celite®, and the filter media was washed with DCM. The filtrate was concentrated under reduced pressure, then purified by column chromatography (eluting with 5-20% methanol in DCM) to yield the title product as a cream foam (354 mg, 84%);

Provenance & Evidence