Methanol → HCID 25158768, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 2-[(2-amino-6-methylsulfanyl-5-nitro-pyrimidin-4-yl)-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl]amino]acetate (Intermediate 26)(212 mg) in glacial acetic acid (5 mL) stirred at 70° C. was added iron powder (120 mg). The reaction mixture was heated at 70° C. for 30 minutes then allowed to cool to room temperature. The reaction mixture was filtered, the filtrate evaporated to dryness and azeotroped with toluene to give a brown gum. This material was stirred with 5% methanol in DCM (10 mL) and then filtered to remove iron residues. The filtrate was purified by flash chromatography on silica eluting with an increasingly polar gradient of methanol/DCM (0/100 to 5/95) to give the title compound (52 mg) as a beige solid. 1H NMR spectrum (400 MHz, DMSO-d6) 2.11 (6H, s), 2.37 (3H, s), 3.66 (3H, s), 3.88 (2H, s), 4.68 (2H, s), 5.80 (2H, s), 8.07 (1H, s), 9.34 (1H, s); Mass spectrum: (M+H)+ 361.44.

Provenance & Evidence