4-(4-Fluorophenoxy)piperidine → HCID 23630217, compound

HRID 1714861Notes

Reaction equation

HRID 1714861 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]([NH:10][CH2:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[O:9])=[CH:4][CH:3]=1.[F:16][C:17]1[CH:29]=[CH:28][C:20]([O:21][CH:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[CH:19][CH:18]=1>>[CH:13]1([CH2:12][CH2:11][NH:10][C:8]([C:5]2[N:6]=[N:7][C:2]([N:25]3[CH2:24][CH2:23][CH:22]([O:21][C:20]4[CH:28]=[CH:29][C:17]([F:16])=[CH:18][CH:19]=4)[CH2:27][CH2:26]3)=[CH:3][CH:4]=2)=[O:9])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 37348964-(4-Fluorophenoxy)piperidineHCID 655615656-Chloro-N-(2-cyclopropylethyl)pyridazine-3-carboxamide

Product 1

HCID 23630217HCID 23630217, compound

Procedure

The title compound was prepared in the same manner as described for Example 1, step 3 from 6-chloro-N-(2-cyclopropylethyl)pyridazine-3-carboxamide and 4-(4-fluorophenoxy)piperidine. 1H NMR (500 MHz, acetone-d6): δ 0.11-0.13 (m, 2H), 0.45-0.49 (m, 2H), 0.76-0.84 (m, 1H), 1.56 (q, 2H), 1.78-1.85 (m, 2H), 2.08-2.16 (m, 2H), 3.54 (q, 2H), 3.70-3.76 (m, 2H), 4.16-4.22 (m, 2H), 4.69-4.75 (m, 1H), 7.05-7.11 (m, 4H), 7.34 (d, 1H), 7.91 (d, 1H), 8.24 (s, 1H); MS (+ESI) m/z 385 (MH+).

Sources & evidence

ORD record
ord-4bf0b89fd5a44b519462876b1e6f5e6e
Source dataset
uspto-grants-2010_09
Patent number
US07799787B2

Reaction notes

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