Acetic Acid → 1-Cyclopropyl-2-nitroethan-1-ol

Participants

Reaction Steps

To a solution of cyclopropanecarbaldehyde (1.4 g, 20 mmol) and nitromethane (1.2 g, 20 mmol) in MeOH at 0° C. was added a solution of NaOH (840 mmol, 21 mmol) in water (8 mL). The mixture was stirred at room temperature for 1 h and then HOAc (1.3 mL) was added. Volatile solvent was removed in vacuo. The residue was diluted with water and extracted twice with EtOAc. The combined EtOAc extracted was washed with brine, dried (Na2SO4) and concentrated to give the title compound as a yellow liquid.

Provenance & Evidence