3,6-Dichloropyridazine → HCID 57647129, compound

HRID 1714870Notes

Reaction equation

HRID 1714870 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:15]=[CH:14][CH:13]=[CH:12][C:4]=1[O:5][CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.[Cl:18][C:19]1[N:20]=[N:21][C:22](Cl)=[CH:23][CH:24]=1>>[Cl:18][C:19]1[N:20]=[N:21][C:22]([N:9]2[CH2:10][CH2:11][CH:6]([O:5][C:4]3[CH:12]=[CH:13][CH:14]=[CH:15][C:3]=3[C:2]([F:1])([F:16])[F:17])[CH2:7][CH2:8]2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 673313,6-DichloropyridazineHCID 50187904-[2-(Trifluoromethyl)phenoxy]piperidine

Product 1

HCID 57647129HCID 57647129, compound

Procedure

The title compound was prepared in the same manner as described for Example 1 Step 3 from 4-[2-(trifluoromethyl)phenoxy]piperidine and 3,6-dichloropyridazine. 1H NMR (400 MHz, acetone-d6): δ 1.89-1.99 (m, 2H), 2.11-2.23 (m, 3H), 3.78-3.84 (m, 2H), 3.91-3.97 (m, 2H), 4.98-5.04 (m, 1H), 7.12 (t, 1H), 7.41 (q, 3H), 7.61-7.67 (m, 2H). MS (+ESI) m/z 358 (MH+).

Sources & evidence

ORD record
ord-cf46cb344cda444fb6e17693806037de
Source dataset
uspto-grants-2010_09
Patent number
US07799787B2

Reaction notes

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