Sodium Methoxide → HCID 57647143, compound

Participants

Reaction Steps

A solution of 3-chloro-6-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridazine (150 mg, 0.42 mmol) in MeOH (1 mL) and NaOMe (2.5 mL, 0.87 mmol, 25-30% in MeOH) was heated at 80° C. After 4 h, solvent was evaporated and the mixture was diluted with water (3 mL), extracted with EtOAc (3×2 mL) and dried over Na2SO4. Evaporation of the solvent followed by purification Combiflash chromatography (SiO2, eluant 30-40% EtOAc/hexanes) afforded the desired product. 1H NMR (500 MHz, acetone-d6): δ 1.87-1.95 (m, 2H), 2.07-2.14 (m, 2H), 3.58-3.64 (m, 2H), 3.78-3.86 (m, 2H), 3.97 (s, 3H), 4.90-5.00 (m, 1H), 6.94 (d, 1H), 7.08-7.12 (m, 1H), 7.35 (t, 2H), 7.59-7.65 (m, 2H). MS (+ESI) m/z 354 (MH+).

Provenance & Evidence