HCID 12254291, compound → HCID 68451359, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 8 g (55 mmoles) of 2-ethyl-indolizine and 13.1 g (60 mmoles) of 4-(3-chloropropyl)benzoyl chloride was heated to 50° C. for 18 hours. It was taken up in water, extracted with dichloromethane, washed with a sodium carbonate solution; the organic phase was then dried over sodium sulphate and concentrated to dryness. It was purified by flash chromatography over alumina (eluent: cyclohexane/methylene chloride, 50/50). In this manner, 17 g of the desired compound was obtained in the form of an oil. Yield: 94%.

Provenance & Evidence