Sodium Hydroxide → Disodium 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-2,3-pyridinedicarboxylate

HRID 1714985Notes

Reaction equation

HRID 1714985 reaction equation
[OH-].[Na+:2].[CH:3]1([N:7]2[CH2:13][CH2:12][C:11]3[CH:14]=[CH:15][C:16]([O:18][C:19]4[N:24]=[C:23]([C:25]([O:27]C)=[O:26])[C:22]([C:29]([O:31]C)=[O:30])=[CH:21][CH:20]=4)=[CH:17][C:10]=3[CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4]1>O.C(O)C>[CH:3]1([N:7]2[CH2:13][CH2:12][C:11]3[CH:14]=[CH:15][C:16]([O:18][C:19]4[N:24]=[C:23]([C:25]([O-:27])=[O:26])[C:22]([C:29]([O-:31])=[O:30])=[CH:21][CH:20]=4)=[CH:17][C:10]=3[CH2:9][CH2:8]2)[CH2:4][CH2:5][CH2:6]1.[Na+:2].[Na+:2]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 10070139Dimethyl 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-2,3-pyridinedicarboxylate

Product 1

HCID 10365123Disodium 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-2,3-pyridinedicarboxylate

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Sodium hydroxide (0.66 g) in water (3 ml) was added to a solution of dimethyl 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-2,3-pyridinedicarboxylate (E231) (1.69 g, 4.12 mmol) in ethanol (20 ml) at room temperature. The mixture was vigorously stirred at room temperature for 4 h and the resulting precipitate filtered off to give the title compound as a colourless solid (E232); MS (ES+) m/e 383 [M+H]+.

Workup

  1. filtrationthe resulting precipitate filtered off

Sources & evidence

ORD record
ord-ab0acf98c3d946c8bef7aeb517ecdb50
Source dataset
uspto-grants-2010_09
Patent number
US07799773B2

Reaction notes

Loading…