Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N,N-Diethyl-2-propanamine | HCID 521913 | — |
| Reactant | Pyrazole-1-carboxamidine monohydrochloride | HCID 2734672 | — |
| Reactant | C-(6-Benzenesulfonyl-naphthalen-1-yl)-methylamine | HCID 59028770 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178512748 | HCID 178512748 | — |
Reaction Steps
C-(6-Benzenesulfonyl-naphthalen-1-yl)-methylamine, 1H-pyrazol-1-carboxamidine hydrochloride and diethyl isopropylamine are dissolved in DMF, and the reaction mixture is heated to 100° C., then cooled and diluted by addition of water. The aqueous mixture is extracted with EtOAc, and the combined organic layers are dried over MgSO4, filtered, and concentrated under reduced pressure to give N-(6-benzenesulfonyl-naphthalen-1-ylmethyl)-guanidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07799797B2 |
|---|
| Source dataset | uspto-grants-2010_09 |
|---|
| ORD ID | ord-a61a7794ce7d4db1a72b279678111e0e |
|---|
| Source note | uspto-grants-2010_09 |
|---|
