1H-Imidazole, 4,5-dihydro-2-(methylthio)-, hydriodide (1:1) → (6-benzenesulfonyl-naphthalen-1-ylmethyl)-(4,5-dihydro-1H-imidazol-2-yl)-amine

Participants

Reaction Conditions

Reaction Steps

C-(6-Benzenesulfonyl-naphthalen-1-yl)-methylamine and 2-methylsulfanyl-4,5-dihydro-1H-imidazole hydroiodide were added to methylene chloride and the reaction mixture was heated to reflux until all of the solvent evaporates. The reaction mixture is heated to 150° C. and then cooled. The resulting mixture is basified by dropwise addition of aqueous NaOH solution, and then purified by preparative liquid chromatography to give (6-benzenesulfonyl-naphthalen-1-ylmethyl)-(4,5-dihydro-1H-imidazol-2-yl)-amine.

Provenance & Evidence