HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → {[(6-Benzenesulfonyl-naphthalen-1-ylmethyl)-carbamoyl]-methyl}-methyl-carbamic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | N-Carbobenzoxysarcosine | HCID 97053 | — |
| Reactant | 3-(Dimethylamino)propyl-ethyl-(iminomethylidene)azanium | HCID 21883392 | — |
| Reactant | C-(6-Benzenesulfonyl-naphthalen-1-yl)-methylamine | HCID 59028770 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | {[(6-Benzenesulfonyl-naphthalen-1-ylmethyl)-carbamoyl]-methyl}-methyl-carbamic acid benzyl ester | HCID 59028785 | — |
Reaction Steps
A mixture of C-(6-benzenesulfonyl-naphthalen-1-yl)-methylamine, (Benzyloxycarbonyl-methyl-amino)-acetic acid, 1-hydroxybenzotriazole, N-(3-dimethylaminopropyl)-N-ethylcarbodiimide and triethylamine in methylene chloride is stirred at room temperature. The reaction is quenched by addition of water, and the mixture is eluted through silica gel to give {[(6-Benzenesulfonyl-naphthalen-1-ylmethyl)-carbamoyl]-methyl}-methyl-carbamic acid benzyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07799797B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-cc15183b75a5437b983dc5b53a7b1879 |
| Source note | uspto-grants-2010_09 |