(4-Amino-3-bromothieno[3,2-c]pyridin-7-yl)methanol → 4-Amino-3-bromothieno[3,2-c]pyridine-7-carbaldehyde

Participants

Reaction Steps

A solution of Example 277E (1 g, 3.86 mmol) in THF (100 mL) was treated with MnO2 (2.66 g, 42.1 mmol), stirred overnight at room temperature, and filtered through diatomaceous earth (Celite®). The pad was washed with THF and dichloromethane and the combined filtrates were concentrated to provide 0.88 g (89% yield) of the desired product. MS (ESI(+)) m/e 256.8, 258.8 (M+H)+.

Provenance & Evidence