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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1715151Generated: October 30, 2026

Iodoethane → 3-Ethoxy-4-methylbenzaldehyde

https://huagongshe.com/reaction/1715151

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIodoethaneHCID 6340—
ReactantPotassium CarbonateHCID 11430—
Reactant3-Hydroxy-4-methylbenzaldehydeHCID 585182—
SolventDimethylformamideHCID 6228—
Product3-Ethoxy-4-methylbenzaldehydeHCID 25242058—

Reaction Steps

The title compound was prepared by reaction of commercially available 3-hydroxy-4-methyl-benzaldehyde with ethyl iodide in DMF using K2CO3 as base in analogy to the procedure described in M. J. Ashton, D. C. Cook, G. Fenton, J.-A. Karlsson, M. N. Palfreyman, D. Raeburn, A. J. Ratcliffe, J. E. Souness, S. Thurairatnam and N. Vicker J. Med. Chem. 1994, 37, 1696-1703.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07799806B2
Source datasetuspto-grants-2010_09
ORD IDord-c85d7a67e24948c4a81d68c013fc906b
Source noteuspto-grants-2010_09