1,1'-Carbonyldiimidazole → HCID 59323900, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-[4-(2-amino-4-methyl-thiazol-5-yl)-phenyl]-ethanone (0.57 g, 2.45 mmol) is dissolved in a mixture of THF (10 ml) and DCM (20 ml) and heated in an oil bath set to 50° C. CDI is added (0.64 g, 3.92 mmol) and the reaction mixture heated at 50° C. for a further 2 hours in which a pale yellow precipitate forms. After cooling to room temperature the precipitate is filtered, washed with DCM and dried under high vacuum to yield the title compound.

Provenance & Evidence