Cesium carbonate → HCID 59323903, compound

Participants

Reaction Conditions

Reaction Steps

Dry, degassed DMF (25 ml) is added to 1-(4-bromo-2-fluoro-phenyl)-ethanone (WO 2003095441) (1.25 g, 5.76 mmol), N-(4-methyl-thiazol-2-yl)-acetamide (0.75 g, 4.80 mmol), Bis (tri-t-butylphosphine) palladium (0) (0.245 g, 0.48 mmol) and caesium carbonate (3.13 g, 9.60 mmol), and the reaction mixture heated to 150° C. for 4 hours. The reaction mixture is filtered through celite and the filtrate reduced in vacuo. Purification of the crude product by chromatography on silica eluting with 2:1 iso-hexane:EtOAc affords the title compound as a yellow solid. (MH+) 293.25

Provenance & Evidence