HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 24688528, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Aminopyridine | HCID 10009 | — |
| Reactant | N-((1,1-dimethylethoxy)carbonyl)-beta-alanine | HCID 76809 | — |
| Reactant | HOAt | HCID 181649 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 24688528 | HCID 24688528 | — |
Reaction Steps
TEA (2.2 ml, 16 mmol) is added to a stirred solution of BOC-β-alanine (2.4 g, 12.7 mmol), HOAt (0.68 g, 5.0 mmol), EDCl.HCl (2.43 g, 12.7 mmol) in DCM and stirred at room temperature. After 1 hour, 3-aminopyridine (1.0 g, 10.6 mmol) is added and the mixture is stirred at room temperature for a further 3 hours. The mixture is then diluted with DCM (200 ml) and washed with 0.1 M HCl followed by 1M NaOH. The organic portion is dried (MgSO4) and concentrated in vacuo to afford the title compound as a white crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07799810B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-8fcebc1266d04f0482a40d0d399c53b0 |
| Source note | uspto-grants-2010_09 |