N-((1,1-dimethylethoxy)carbonyl)-beta-alanine → HCID 68507383, compound

Participants

Reaction Steps

A mixture comprising BOC-β-alanine (1 g, 5.29 mmol), WSCD (0.985 g, 6.34 mmol) and HOAT (0.216 g, 1.59 mmol) in DCM is treated with 3-aminoisoxazole (0.43 ml, 5.81 mmol) and left stirring overnight. The resulting mixture is washed with water, brine, dried (MgSO4) and concentrated in vacuo. The crude product is purified by chromatography on silica eluting with EtOAc to afford the title compound as a white solid.

Provenance & Evidence