Water → HCID 23642173, compound

Participants

Reaction Steps

A mixture of 3-amino-N-(5-methyl-isoxazol-3-yl)-propionamide hydrochloride (Intermediate B1 produced by HCl deprotection) (0.1 g, 0.49 mmol) and triethylamine (0.164 ml, 1.18 mmol) is stirred in DMF (4 ml). Imidazole-1-carboxylic acid [4-methyl-5-(4-pyrazol-1-yl-phenyl)-thiazol-2-yl]-amide (Intermediate A2) (0.16 g, 0.47 mmol) is added and the mixture stirred at room temperature for 18 h. Water (20 ml) is added and the mixture stirred for 30 min. The solid is filtered off, washed with water and dried in vacuo at 45° C. for 4 h to afford the title compound.

Provenance & Evidence