反应详情

温度

80 °C

To a solution of 2-bromopyrimidine (0.88 g) in dry tetrahydrofuran (30 mL) 1-(phenylmethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-dihydro-1H-pyrrole (P13, 1.21 g), tetrakis(triphenylphosphine)palladium(0) (0.25 g) and cesium fluoride (2.59 g) were added at room temperature. The resulting mixture was stirred at 80° C. for 6 hours. After cooling the solvent was evaporated under reduced pressure, the residue partitioned between ether and water and the organic phase was evaporated under reduced pressure. The crude product was purified by silica gel column chromatography (eluting with DCM/MeOH from 100% to 96%) to give 0.23 g of the title compound.

1. temperatureAfter cooling the solvent
2. customwas evaporated under reduced pressure
3. customthe residue partitioned between ether and water
4. customthe organic phase was evaporated under reduced pressure
5. customThe crude product was purified by silica gel column chromatography (eluting with DCM/MeOH from 100% to 96%)