1H-Pyrrolo(2,3-b)pyridine → HCID 66725584, compound
Reaction equation
[NH:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.N1C2=NC=[CH:17][CH:18]=[C:13]2[CH:12]=[CH:11]1>>[CH2:11]([N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1)[CH2:12][CH2:13][CH2:18][CH3:17]Participants
3
Procedure
Following the procedure as described in PREPARATION 1A, and making non-critical variations using 1H-pyrrolo[3,2-b]pyridine to replace 1H-pyrrolo[2,3-b]pyridine, the title compound was obtained (75%) as a yellow oil: 1H NMR (300 MHz, CDCl3) δ 8.39 (d, 1H), 7.56 (d, 1H), 7.25 (d, 1H), 7.05-7.01 (m, 1H), 6.63 (d, 1H), 4.05-3.99 (m, 2H), 1.79-1.72 (m, 2H), 1.31-1.45 (m, 4H), 0.81 (t, 3H); 13C NMR (75 MHz, CDCl3) δ 146.8, 142.9, 131.0, 128.9, 116.5, 116.1, 102.0, 46.6, 30.0, 29.0, 22.2, 14.0; MS (ES+) m/z 189.3 (M+1).
Sources & evidence
- ORD record
- ord-a3e3cf9300d245fea312bf53ee412e06
- Source dataset
- uspto-grants-2010_09
- Patent number
- US07799798B2
Reaction notes
Loading…