Acetic Anhydride → HCID 68409396, compound

HRID 1715231Notes

Reaction equation

HRID 1715231 reaction equation
Cl.[CH3:2][C:3]1[N:4]=[C:5]([NH:11][C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[S:6][C:7]=1[C:8](=[O:10])[CH3:9].[C:18](OC(=O)C)(=[O:20])[CH3:19]>>[C:8]([C:7]1[S:6][C:5]([N:11]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[C:18](=[O:20])[CH3:19])=[N:4][C:3]=1[CH3:2])(=[O:10])[CH3:9]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 131728329HCID 131728329, compound

Product 1

HCID 68409396HCID 68409396, compound

Conditions

Temperature
150 °C

Procedure

In a tube, 1-[4-Methyl-2-(pyrazin-2-ylamino)-1,3-thiazol-5-yl]ethanone, hydrochloride salt (500 mg; 1.85 mmol; 1 eq.) is mixed with acetic anhydride (2.16 ml; 22.90 mmol; 12.40 eq.). The tube is sealed and is heated at 150° C. with an oil bath. After 15 min, the mixture becomes yellow. The reaction is complete. The solvents are removed and N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-N-pyrazin-2-ylacetamide is used as such without further purification (510.3 mg; quantitative).

Workup

  1. customThe tube is sealed
  2. customThe solvents are removed
  3. customsuch without further purification (510.3 mg; quantitative)

Sources & evidence

ORD record
ord-1dbf8c34e1d44c54ac3e0a13aeda307c
Source dataset
uspto-grants-2010_09
Patent number
US07799814B2

Reaction notes

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