HCID 178418361, compound → HCID 178507464, compound

Participants

Reaction Steps

In a flask, is dissolved 5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol (4.50 g; 21.72 mmol; 1 eq.) in MeOH (150 ml) under inert atmosphere. Palladium 10% on charcoal (2.31 g; 2.17 mmol; 0.10 eq.) is added and the reaction mixture is stirred 5 minutes at rt. The mixture is then put under atmospheric pressure of hydrogen. The reaction is completed after 2 hours. The mixture is filtrated on celite and rinced with MeOH. The solvents are evaporated under vacuo, affording 5-(4-aminophenyl)-1,3,4-oxadiazol-2-ol as a white powder (2.34 g; 61%).

Provenance & Evidence