1,1'-Carbonyldiimidazole → 5H,6H,7H,8H-imidazo(1,5-c)pyrimidin-5-one

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(1H-imidazol-4-yl)ethanamine (26.8 g; 240.9 mmol; 1 eq) and CDI (39.1 g; 240.9 mmol; 1 eq) in DMF (401.7 ml) is stirred at 50° C. for two days. The mixture is concentrated to 100 ml and acetonitrile (200 ml) is added. The resulting precipitate is filtered, washed with acetonitrile (2×50 ml) and dried under vacuum, affording the title compound that is used in the next step without further purification (28.3 g; 85%).

Provenance & Evidence