Hydrochloric Acid → HCID 11989749, compound

Participants

Reaction Steps

Sodium hydroxide 5N solution (109 μl; 5 M; 0.55 mmol; 12.50 eq.) is added to a solution of 2′-(acetylamino)-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-6-yl)-4′-methyl-4,5′-bi-1,3-thiazole-2-carboxamide, obtained in Step I as described above (20 mg; 0.04 mmol; 1 eq.) in THF (1 ml) at rt. After 50 min, the deprotection is complete. Hydrogen chloride (109 μl; 5 M; 0.55 mmol; 12.50 eq.) is added, followed by water (2 ml). The resulting precipitate is isolated by filtration, washed with water and dried under vacuo. Compound (22) is isolated as yellow solid (14 mg; 77%).

Provenance & Evidence