Trifluoroacetic acid → HCID 11988391, compound

Participants

Reaction Steps

Tert-butyl 4-{[2-(cyanomethyl)-4′-methyl-4,5′-bi-1,3-thiazol-2′-yl]amino}-4-oxobutanoate, Compound (58), (63 mg; 0.16 mmol; 1 eq.), is dissolved in DCM (3 ml). Trifluoroacetic acid (0.16 ml; 2.09 mmol; 13 eq) is added dropwise and the reaction mixture is stirred at RT. The solvents are evaporated and the crude product is purified by preparative HPLC, affording Compound (63) as a white-off solid (54 mg; 29%).

Provenance & Evidence