4-Ethynylaniline → HCID 24770939, compound

Participants

Reaction Steps

To a solution of 2-trifluoromethyl-biphenyl-4-carbaldehyde oxime (1 eq) in CH2Cl2 a 10% aqueous solution of NaOCl is added at 0° C. Thereafter a solution of 4-ethynylaniline (1.1 eq) is added and then the reaction mixture is stirred at room temperature for 16 hours. The reaction mixture is diluted with CH2Cl2 and 3 times extracted with water. The combined organic layers are dried over Na2SO4, filtered and concentrated. Purification is achieved, after drying over Na2SO4, over silica gel using c-hexane/ethyl acetate 9/1→7/3 as mobile phase.

Provenance & Evidence